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Highly Versatile Polyelectrolyte Complexes for Improving the Enzyme Replacement Therapy of Lysosomal Storage

Marina I Giannotti1,2,3, Ibane Abasolo1,4, Mireia Oliva1,2,5

  • 1Centro de Investigación Biomédica en Red-Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) , 28029 Madrid, Spain.

ACS Applied Materials & Interfaces
|September 10, 2016
PubMed
Summary

This study introduces a novel drug delivery system using polyelectrolyte complexes (PECs) for enzyme replacement therapy (ERT) in lysosomal storage disorders. RGD-targeted PECs enhance enzyme uptake and efficacy, offering a promising approach for treating Fabry disease.

Keywords:
Fabry diseaseenzyme replacement therapylysosomal deliverynanomedicinepolyelectrolyte complexestrimethyl chitosanα-galactosidase A

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