Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Strategy for pacemaker implantation following transcatheter tricuspid valve replacement: A real world single centre experience.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2025

Same author

Passive versus active educational interventions for nevus and melanoma classification: A randomized controlled study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025

Same author

Effectiveness of Baricitinib in Alopecia Areata Patients With a Current Episode Lasting Longer Than 8 Years: An Italian Multicenter Real-Life Experience in the Lazio Region.

International journal of dermatology·2025

Same author

Eccentric hypertrophy impairs outcome after TAVR.

Clinical research in cardiology : official journal of the German Cardiac Society·2024

Same author

Safe Integration of Encorafenib plus Binimetinib with Stereotactic Radiosurgery for Melanoma Brain Metastases: a Case Report.

La Clinica terapeutica·2024

Same author

Correction: <i>Lactiplantibacillus plantarum</i> HEAL9 attenuates cognitive impairment and progression of Alzheimer's disease and related bowel symptoms in SAMP8 mice by modulating microbiota-gut-inflammasome-brain axis.

Food & function·2024

Search research articles

Related Experiment Video

Updated: Mar 15, 2026

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

Intestinal dysfunction in Parkinson's disease: Lessons learned from translational studies and experimental models.

C Pellegrini¹, R Colucci², L Antonioli¹

¹Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Neurogastroenterology and Motility

|September 10, 2016

Summary

Parkinson's disease (PD) may start in the gut, with digestive issues preceding motor symptoms. Research explores how gut inflammation and altered nerve pathways contribute to PD's progression and motor dysfunction.

Keywords:

Parkinson's disease colonic motility patients preclinical model small bowel alterations

More Related Videos

Assessing Gastrointestinal Motility in Caenorhabditis elegans RAC1/CED-10 Mutants as a Tool to Study Early Parkinson's Disease

Assessing Gastrointestinal Motility in Caenorhabditis elegans RAC1/CED-10 Mutants as a Tool to Study Early Parkinson's Disease

Published on: November 28, 2025

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

Related Experiment Videos

Last Updated: Mar 15, 2026

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

Assessing Gastrointestinal Motility in Caenorhabditis elegans RAC1/CED-10 Mutants as a Tool to Study Early Parkinson's Disease

Assessing Gastrointestinal Motility in Caenorhabditis elegans RAC1/CED-10 Mutants as a Tool to Study Early Parkinson's Disease

Published on: November 28, 2025

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

Area of Science:

Neuroscience
Gastroenterology
Pathology

Background:

Digestive dysfunction is common in Parkinson's disease (PD), often appearing before motor symptoms.
The hypothesis that PD originates in the gut is supported by alpha-synuclein aggregates (Lewy bodies) in the enteric nervous system.
Gut inflammation and oxidative stress may contribute to nigrostriatal neurodegeneration in PD.

Purpose of the Study:

To critically review knowledge on enteric neuromuscular pathway alterations in PD.
To examine the role of neuro-immune mechanisms in gastrointestinal dysfunction in PD.
To discuss findings in both human patients and preclinical PD models.

Main Methods:

Literature review and critical appraisal of existing research.
Analysis of studies on enteric nervous system function in PD.
Examination of evidence linking gut inflammation to PD pathophysiology.

Main Results:

Alterations in enteric neurotransmission are implicated in PD-related intestinal motility disturbances.
Neuro-immune interactions play a significant role in aberrant gut activity in PD.
Preclinical models and human studies show consistent patterns of gastrointestinal involvement.

Conclusions:

The gut is a key area for understanding PD initiation and progression.
Enteric neuromuscular and neuro-immune pathways are critical targets for PD research.
Further investigation into gut-brain axis in PD is warranted.