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2-cyclohexene-1-one-induced hyperglycemia in the mice
1Department of Biology and Clinical Physiology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
Japanese Journal of Pharmacology
|July 1, 1989
Abstract:
2-Cyclohexene-1-one (CHX) dose-dependently caused the elevation of blood glucose levels in both fed and fasted mice. Adrenalectomy considerably prevented the elevated blood glucose with CHX, and plasma adrenaline assays revealed about a three- to fifteen-fold rise after CHX treatment. These findings indicate that the CHX-induced hyperglycemia may be largely mediated by adrenaline released from the adrenal medulla.