Related Experiment Video

Updated: Mar 15, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

8.4K

Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter

Manuel Sánchez-Luna1, Constancio Medrano2, Julián Lirio3

  • 1Neonatology Division, Hospital Materno Infantil, Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid, Spain.

Influenza and Other Respiratory Viruses
|September 10, 2016
PubMed

Insights

Infants with Down syndrome (DS) have higher hospitalization rates for respiratory syncytial virus (RSV) infections. These infants may benefit from RSV immunoprophylaxis recommendations.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Genetics

Background:

  • Respiratory syncytial virus (RSV) poses a significant health risk, especially to infants.
  • Premature infants are particularly vulnerable to severe RSV infection.

Purpose of the Study:

  • To compare hospitalization rates and disease severity for RSV infections in term infants with and without Down syndrome (DS).
  • To identify risk factors for severe RSV infection in infants.

Main Methods:

  • A prospective, multicenter epidemiological study.
  • 93 infants with DS and 68 matched controls were followed for one year.
  • Data collected included hospitalization rates and RSV prophylaxis usage.

Main Results:

  • Infants with DS had significantly higher hospitalization rates for acute respiratory infections (44.1% vs 7.7%) and RSV infections (9.7% vs 1.5%).
  • RSV immunoprophylaxis was given to 35.5% of infants with DS.
  • Hospitalization rates were lower in infants who received RSV prophylaxis (3.0% vs 15%).

Conclusions:

  • Infants with Down syndrome experience a greater burden of RSV-related hospitalizations.
  • Current recommendations for RSV immunoprophylaxis should consider including infants with DS.
Abstract

Keywords:
Down syndromehospitalizationpalivizumabprospective birth cohort studyrespiratory syncytial virus

More Related Videos

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses11:48

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

17.5K
An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay09:14

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

Published on: January 26, 2019

11.6K

Related Concept Videos

Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
4.5K
Common Respiratory Disorders01:31

Common Respiratory Disorders

Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
1.7K
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
1.2K
Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
66.0K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.5K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.4K