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Mammary gland growth and response to hormones in mastomys compared with mice
H Nagasawa1, U Koshimizu, M Watanabe
1Experimental Animal Research Laboratory, Meiji University, Kanagawa, Japan.
Laboratory Animal Science
|July 1, 1989
Abstract:
Mammary gland growth with or without hormone manipulation was examined in virgin mastomys (Praomys (mastomys) natalensis) and compared with C3H/He mice having a low mammary tumor incidence. Mammary glands of mastomys consisted mostly of duct systems even at 720 days of age, whereas conspicuous formation of normal end-buds and preneoplastic hyperplastic alveolar nodules were seen in the glands of mice after 180 days of age. Mammary glands of mastomys showed a higher response to estrogen or progesterone rather than prolactin, which is much different from other rodents.