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PDMMLA derivatives as a promising cardiovascular metallic stent coating: Physicochemical and biological evaluation.

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Dynamic contact angle cycling homogenizes heterogeneous surfaces.

R Belibel1, C Barbaud1, L Mora1

  • 1INSERM U1148, Laboratory for Vascular Translational Science (LVTS), Institut Galilée, Université Paris 13, Sorbonne Paris Cité, 99 Avenue Jean-Baptiste Clément, Villetaneuse F-93430, France.

Materials Science & Engineering. C, Materials for Biological Applications
|September 11, 2016
PubMed
Summary
This summary is machine-generated.

Biodegradable polymer coatings for metallic stents were developed using poly((R,S)-3,3 dimethylmalic acid) (PDMMLA). Advancing contact angle and hysteresis measurements effectively characterize surface properties, crucial for drug-eluting stent development.

Keywords:
Biodegradable (poly((R,S)-3,3 dimethylmalic acid)) derivativesBiopolyestersContact angleHeterogeneous surfacesHydrophobicitySessile dropWilhelmy balance

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surface Science

Background:

  • Reducing restenosis after metallic stent implantation necessitates advanced coating materials.
  • Biodegradable polymers offer potential for drug delivery and improved biocompatibility in cardiovascular devices.

Purpose of the Study:

  • To synthesize and characterize biodegradable poly((R,S)-3,3 dimethylmalic acid) (PDMMLA) copolymers for stent coatings.
  • To investigate the influence of surface chemistry, specifically acidic and hexylic groups, on the wettability and dynamic surface properties of these PDMMLA coatings.
  • To evaluate the effectiveness of Dynamic Surface Analysis compared to Cassie theory for characterizing heterogeneous polymer surfaces.

Main Methods:

  • Synthesis of PDMMLA copolymers with varying percentages of acidic groups.
  • Measurement of advancing and receding contact angles and surface hysteresis.
  • Application of Dynamic Surface Analysis through repeated cycling in water.
  • Comparison of experimental results with theoretical predictions from Cassie theory.

Main Results:

  • Advancing contact angle linearly decreases with increasing acidic group percentage (%A) in PDMMLA side chains.
  • Surface hysteresis (H) was identified as a sensitive parameter to %A.
  • Dynamic Surface Analysis, particularly after cycling (H(10)), provided reliable surface characterization, superseding theoretical Cassie corrections for heterogeneous surfaces.

Conclusions:

  • PDMMLA copolymers are promising candidates for drug-carrying stent coatings due to tunable surface properties.
  • Dynamic Surface Analysis is a practical and effective method for characterizing the heterogeneous surfaces of these advanced biomaterials.
  • Surface wettability and hydrolysis kinetics are significantly influenced by the chemical composition and dynamic surface behavior of the polymer coating.