Related Experiment Video
Updated: Mar 15, 2026
03:45
Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
Published on: May 5, 2023
3.5K
Recent advancements in regenerative dentistry: A review.
Pouya Amrollahi1, Brinda Shah2, Amir Seifi2
1Helmerich Advanced Technology Research Center, School of Material Science and Engineering, Oklahoma State University, Tulsa, OK 74106, USA.
Materials Science & Engineering. C, Materials for Biological Applications
|September 11, 2016
Summary
Regenerative dentistry uses stem cells, biomaterials, and growth factors to repair damaged oral tissues. While partial regeneration is successful, complete tooth engineering requires further research to overcome current limitations.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Dental Research
Background:
- The human mouth is susceptible to damage, necessitating advanced restorative solutions beyond conventional dentistry.
- Traditional dental restorations have limitations in lifespan and efficacy.
- Regenerative dentistry emerges as a promising field leveraging medical advancements for oral health.
Purpose of the Study:
- To review current resources and approaches for dental and oral tissue regeneration.
- To evaluate the application of tissue engineering in dentistry.
Main Methods:
- Systematic literature review using Scopus and Web of Science databases.
- Analysis of studies employing biomaterials, scaffolds, gene therapy, stem cells, and growth factors for dental regeneration.
Main Results:
- Successful preclinical and clinical partial regeneration of dental tissues has been achieved.
- Various stem cell sources (e.g., dental pulp, adipose tissue) and biomaterials are utilized.
- Gene therapy and growth factors are employed to stimulate cell differentiation and tissue repair.
Conclusions:
- Tissue engineering approaches show significant potential in regenerative dentistry.
- Complete whole-tooth regeneration remains a long-term goal, pending resolution of existing challenges.
- Continued research is crucial for advancing regenerative dentistry and improving patient outcomes.
