Corticotropin-Releasing Factor Receptors and Their Interacting Proteins: Functional Consequences
Paula G Slater1, Hector E Yarur1, Katia Gysling2
1Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.
Molecular Pharmacology
|September 11, 2016
Summary
The corticotropin-releasing factor (CRF) system, crucial for stress and addiction, involves CRF receptors interacting with other proteins. Understanding these interactions offers new therapeutic avenues for stress-related disorders.
Area of Science:
- Neuroscience
- Pharmacology
- Molecular Biology
Background:
- The corticotropin-releasing factor (CRF) system is implicated in stress, addiction, and anxiety disorders like depression.
- CRF exerts its effects via type-1 and type-2 CRF receptors, which are G-protein-coupled receptors (GPCRs).
Purpose of the Study:
- To review recent advancements in the interactions of CRF receptors with other GPCRs and non-GPCR proteins.
- To elucidate the functional consequences of these protein-protein interactions.
- To explore the therapeutic potential for addiction and stress-related disorders.
Main Methods:
- Literature review focusing on recent research findings.
- Analysis of molecular interactions between CRF receptors and other cellular proteins.
- Synthesis of data on functional outcomes and therapeutic implications.
Main Results:
- CRF receptors engage in complex interactions with various GPCRs and non-GPCR proteins.
- These interactions modulate the signaling pathways of the CRF system.
- Evidence suggests these interactions play a significant role in the pathophysiology of stress and addiction.
Conclusions:
- A deeper comprehension of CRF receptor interactions is essential for advancing treatment strategies.
- Targeting these interactions may yield novel pharmacological interventions for addiction and stress-related conditions.
- Further research into these molecular mechanisms holds promise for developing more effective therapies.
More Related Videos
06:56A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
Published on: March 10, 2018
14.6K
09:49Brain Membrane Fractionation: An Ex Vivo Approach to Assess Subsynaptic Protein Localization
Published on: May 12, 2017
10.9K
Related Concept Videos
01:08Intracellular Hormone Receptors
62.0K
Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
62.0K
01:19Interactions Between Signaling Pathways
7.7K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.7K
01:30Transducer Mechanism: G Protein–Coupled Receptors
6.8K
G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
GPCRs are also called heptahelical,...
6.8K
01:26Secondary Messengers in Hormone Action
5.9K
Water-soluble hormones cannot cross the plasma membrane, so they rely on protein receptors that span the membrane to trigger intracellular signaling pathways. These pathways then activate second messengers inside the cell, including cAMP or calcium ions.
Many hormones bind to transmembrane G protein-coupled receptors that connect to regulatory G proteins. These G proteins can then activate enzymes such as adenylyl cyclase or phospholipase C. Adenylyl cyclase converts ATP to cAMP, activating...
Many hormones bind to transmembrane G protein-coupled receptors that connect to regulatory G proteins. These G proteins can then activate enzymes such as adenylyl cyclase or phospholipase C. Adenylyl cyclase converts ATP to cAMP, activating...
5.9K
01:09GPCRs Regulate Adenylyl Cylase Activity
8.0K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
8.0K
01:22Target Cell Response to Hormones
6.1K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
6.1K