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Visualizing Astrocyte Morphology Using Lucifer Yellow Iontophoresis
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Constant current source for iontophoresis.

M R Park1

  • 1Department of Anatomy and Neurobiology, University of Tennessee, Memphis 38163.

Journal of Neuroscience Methods
|July 1, 1989
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Summary
This summary is machine-generated.

This study introduces a simple, battery-powered current source for iontophoresis, ideal for axonal tracing substances. The novel design avoids operational amplifiers, utilizing bipolar transistors for controlled current delivery.

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Area of Science:

  • Neuroscience
  • Biotechnology
  • Electrical Engineering

Background:

  • Iontophoresis is crucial for delivering neuroactive substances and axonal tracers in neuroscience research.
  • Existing iontophoretic devices often rely on operational amplifiers, which can limit voltage compliance.
  • There is a need for simpler, more versatile current sources for specialized applications like axonal tracing.

Purpose of the Study:

  • To describe a novel, simple, battery-powered current source for iontophoresis.
  • To provide a cost-effective and efficient alternative to existing iontophoretic devices.
  • To facilitate the iontophoresis of axonal tracing substances, such as Phaseolus vulgaris leucoagglutinin.

Main Methods:

  • The design utilizes a pair of bipolar transistors for current regulation.
  • The circuit is battery-powered for portability and ease of use.
  • The transistor selection allows for high voltage compliance (hundreds of volts).

Main Results:

  • A functional, simple, and battery-powered current source was successfully developed.
  • The device is suitable for the iontophoresis of axonal tracing substances.
  • The circuit effectively regulates current without using operational amplifiers.

Conclusions:

  • The described current source offers a practical and effective solution for iontophoresis.
  • This design provides high voltage compliance, expanding its utility in neuroscience.
  • The simplicity and battery power make it an accessible tool for researchers.