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Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System
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Effects of polycyclic aromatic compounds in fine particulate matter generated from household coal combustion on

Kin-Fai Ho1, Chih-Cheng Chang2, Linwei Tian3

  • 1Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong; Shenzhen Municipal Key Laboratory for Health Risk Analysis, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China.

Environmental Pollution (Barking, Essex : 1987)
|September 11, 2016
PubMed

Insights

Indoor coal combustion PM2.5, containing polycyclic aromatic hydrocarbons, may affect lung cancer treatment response to EGFR-tyrosine kinase inhibitors (EGFR-TKI). This finding is crucial for understanding lung cancer in high-pollution areas.

Area of Science:

  • Environmental Science
  • Oncology
  • Toxicology

Background:

  • Lung cancer treatment response to EGFR-tyrosine kinase inhibitors (EGFR-TKI) can be influenced by environmental factors.
  • Particulate matter (PM2.5) from indoor coal combustion contains polycyclic aromatic hydrocarbons (PAHs) and their derivatives, which may impact cancer development and treatment.

Purpose of the Study:

  • To investigate the effect of PM2.5 from indoor coal combustion on the efficacy of EGFR-TKI in lung cancer cells.
  • To characterize the specific chemical components within PM2.5 that may influence EGFR-TKI response.

Main Methods:

  • Collected PM2.5 samples from indoor coal combustion in Xuanwei, China, a high lung cancer incidence region.
  • Exposed human lung adenocarcinoma cell lines (A549 and HCC827) to PM2.5, followed by treatment with EGFR-TKI.
  • Analyzed the chemical composition of PM2.5, including PAHs, oxygenated PAHs (OPAHs), and azaarenes (AZAs).

Main Results:

  • PM2.5 exposure significantly reduced lung cancer cell viability in a dose-dependent manner.
  • EGFR-TKI treatment further decreased cell viability in PM2.5-exposed cells.
  • Specific PAHs, OPAHs, and AZAs were associated with EGFR-TKI-dependent reduced cell viability.

Conclusions:

  • Indoor coal combustion-derived PM2.5 may alter the effectiveness of EGFR-TKI therapy in lung cancer.
  • Understanding the chemical constituents of PM2.5 is vital for predicting and managing lung cancer treatment outcomes in affected populations.
Keywords:
Coal combustionLung cancerPolycyclic aromatic compoundsXuanwei

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