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Updated: Mar 15, 2026

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
Cooccurring Psychiatric and Substance Use Disorders
Zachary D Robinson1, Paula D Riggs2
1Child and Adolescent Psychiatry, Children's Hospital Colorado, University of Colorado Hospital, University of Colorado School of Medicine, 13001 East 17th Place, Campus Box F546, Building 500, Room E2322, Aurora, CO 80045, USA.
Abstract:
Research shows that the majority of adolescents with substance use disorders also have other cooccurring psychiatric disorders, which has been associated with poorer treatment outcomes. Despite considerable consensus that treatment of cooccurring disorders should be integrated or concurrent, most such youth do not receive it. In addition to systemic and economic barriers, few studies have been conducted that inform evidence-based integrated treatment approaches. This article provides a review of current research from which empirically derived principles of integrated treatment can originate and which have informed the development of at least one evidence-based model of integrated mental health and substance treatment.
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