Does Lipid Profile Affect Thrombin Generation During Ramadan Fasting in Patients With Cardiovascular Risks?

Area of Science:

• Cardiovascular Science
• Metabolic Research
• Hematology

Background:

• Diet and lipid metabolism impact blood coagulation.
• The effect of Ramadan fasting on plasmatic coagulation patterns remains largely unknown.
• Cardiovascular disease (CVD) risk factors are prevalent and influence health outcomes.

Purpose of the Study:

• To investigate the impact of Ramadan fasting on thrombin generation (TG) in individuals with CVD risks.
• To assess the relationship between lipid profiles and TG parameters during fasting.
• To compare coagulation patterns between individuals with CVD risks and healthy controls.

Main Methods:

• Study included 36 adults with at least 2 CVD risks and 30 healthy controls.
• Coagulation assessed via classical clotting times and TG tests.
• Lipid profiles measured before and during Ramadan fasting.

Main Results:

• No significant differences in TG parameters between CVD risk patients and controls.
• Ramadan fasting did not affect overall plasmatic coagulation or TG profiles.
• A subset of participants (Group 2) showed increased TG (Mean Rate Index) alongside elevated total cholesterol and LDL cholesterol.
• Increased TG propagation phase correlated with higher cholesterol, but not other TG parameters.

Conclusions:

• Ramadan fasting does not generally alter global coagulation in individuals with CVD risks.
• Changes in lipid profiles during fasting did not influence overall coagulation.
• A specific increase in TG, linked to cholesterol elevation, was observed in a subgroup, suggesting a nuanced effect on coagulation dynamics.