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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Primary Lymphoid Organs01:16

Primary Lymphoid Organs

16.4K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

9.8K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
9.8K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

10.0K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
10.0K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

17.0K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
17.0K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

3.7K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
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Updated: Mar 15, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

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Clonal Lymphoproliferations in a Patient With Common Variable Immunodeficiency.

Sarah A Williams1, Laura E Moench2, Fatima Khan3

  • 1Division of Hematopathology, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA ande8350@umn.edu.

Laboratory Medicine
|September 12, 2016
PubMed
Summary

Common variable immunodeficiency (CVID) can lead to diverse lymphoproliferative disorders. This case highlights the variable nature of these lesions and the need for personalized treatment in CVID patients.

Keywords:
Epstein-Barr virus (EBV), extranodal lymphoma, polymorphous lymphoproliferationscommon variable immunodeficiency (CVID)diffuse large B-cell lymphomalymphoproliferative disorders

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VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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Area of Science:

  • Immunology
  • Oncology

Background:

  • Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinemia and impaired B-cell function.
  • Patients with CVID exhibit increased susceptibility to infections, autoimmune diseases, and lymphoproliferative disorders.

Observation:

  • A Caucasian woman with CVID developed multiple clonal lymphoproliferative lesions over seven years.
  • These lesions displayed a spectrum of morphologic characteristics, with many harboring distinct clonal populations.

Findings:

  • One persistent lesion met the criteria for diffuse large B-cell lymphoma and responded to chemotherapy.
  • Subsequent lymphoproliferations were clonally distinct and managed conservatively.

Implications:

  • Lymphoproliferative lesions in CVID patients are heterogeneous with variable malignant potential.
  • An individualized approach to diagnosis and management is crucial for optimizing patient outcomes.