Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

2.2K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
2.2K
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

2.9K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
2.9K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

10.8K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.8K
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

4.0K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
4.0K
General Transcription Factors01:30

General Transcription Factors

7.4K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
7.4K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.8K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Added value of the measles-rubella supplementary immunization activity in reaching unvaccinated and under-vaccinated children, a cross-sectional study in five Indian districts, 2018-20.

Vaccine·2022
Same author

Exploring inter-organ crosstalk to uncover mechanisms that regulate β-cell function and mass.

European journal of clinical nutrition·2017
Same author

IL-6 alters osteocyte signaling toward osteoblasts but not osteoclasts.

Journal of dental research·2014
Same author

Observed and hypothetical leaf rust progress curves of some genotypes of wheat.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

Relative importance of components affecting the leaf rust progress curve in wheat.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

Heritability estimates of citral content in East Indian lemongrass.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same journal

Relationship Between hsCRP, Glycaemic Control and Response to Sotagliflozin in Type 1 Diabetes: A Post Hoc Analysis of the inTandem3 Trial.

Diabetes, obesity & metabolism·2026
Same journal

Early Weight Regain After GLP-1 Receptor Agonist Discontinuation: Mechanisms and Implications for Treatment De-Escalation Strategies.

Diabetes, obesity & metabolism·2026
Same journal

First-Line Dapagliflozin, Metformin, or Combination Therapy in Type 2 Diabetes: Vascular and Molecular Outcomes of a Randomised Controlled Trial.

Diabetes, obesity & metabolism·2026
Same journal

Trends in Prevalence of Diabetes, Pre-Diabetes, and Cardiometabolic Risk Factor Control Among U.S. Adults, 2013-2023.

Diabetes, obesity & metabolism·2026
Same journal

Metabolic Risk-Attributable Dementia Burden: A Life-Course and Cautious Attribution Perspective.

Diabetes, obesity & metabolism·2026
Same journal

A Highly Powered Large Outcomes Randomised Controlled Trial Will Usually, but Not Always, Have Balanced Groups at Baseline.

Diabetes, obesity & metabolism·2026
See all related articles

Related Experiment Video

Updated: Mar 15, 2026

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
09:35

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

11.7K

Novel factors modulating human β-cell proliferation.

J Shirakawa1,2, R N Kulkarni3,4,5

  • 1Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, Massachusetts.

Diabetes, Obesity & Metabolism
|September 13, 2016
PubMed
Summary
This summary is machine-generated.

Enhancing human beta-cell proliferation is key to restoring beta-cell mass for diabetes treatment. Several compounds, including kinase and receptor inhibitors, show promise in promoting beta-cell replication.

Keywords:
GNF4877SerpinB1WS6harminehuman β-cell proliferationosteoprotegrin

More Related Videos

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
09:31

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres

Published on: November 5, 2016

7.7K
High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
12:32

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds

Published on: January 23, 2018

13.1K

Related Experiment Videos

Last Updated: Mar 15, 2026

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
09:35

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

11.7K
Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
09:31

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres

Published on: November 5, 2016

7.7K
High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
12:32

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds

Published on: January 23, 2018

13.1K

Area of Science:

  • Endocrinology
  • Cell Biology
  • Diabetes Research

Background:

  • Beta-cell dysfunction and loss are central to type 1 and type 2 diabetes.
  • Restoring beta-cell mass through proliferation is a promising therapeutic strategy.

Purpose of the Study:

  • To review recent advancements in promoting human beta-cell proliferation.
  • To identify key proteins and pathways that regulate beta-cell mass.

Main Methods:

  • Review of studies on compounds that enhance beta-cell replication.
  • Analysis of inhibitors targeting specific kinases (DYRK1A, GSK-3β) and pathways (NF-kB).

Main Results:

  • WS6 (IkB kinase and EBP1 inhibitor) demonstrated beta-cell proliferation.
  • Harmine, 5-IT, GNF7156, and GNF4877 (DYRK1A and GSK-3β inhibitors) showed efficacy.
  • Osteoprotegrin, Denosmab (RANK inhibitors), and SerpinB1 (protease inhibitor) also supported proliferation.

Conclusions:

  • Several novel compounds and pathways offer potential for enhancing human beta-cell proliferation.
  • These findings provide a basis for developing new diabetes therapies targeting beta-cell regeneration.