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Enhanced Rho-kinase activity: Pathophysiological relevance in type 2 diabetes
Lei Liu1, Lun Tan1, Jinsheng Lai1
1Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|September 13, 2016
Summary
Rho-associated kinase (ROCK) activity is elevated in type 2 diabetes patients. This increased ROCK activity correlates with higher HbA1c levels, suggesting it may indicate disease progression.
Area of Science:
- Biochemistry
- Endocrinology
- Molecular Biology
Background:
- Rho-associated kinase (ROCK) is implicated in insulin resistance and diabetes pathogenesis.
- Clinical evidence of ROCK activity in diabetic patients remains limited.
- This study investigates systemic ROCK activity in type 2 diabetes.
Purpose of the Study:
- To determine if ROCK activity is elevated in type 2 diabetic patients.
- To assess the association between ROCK activity and diabetes-related factors.
Main Methods:
- Seventy-eight participants (41 type 2 diabetes, 37 controls) were enrolled.
- Fasting blood samples measured ROCK activity via phosphorylation/total myosin-binding subunit (MBS) ratio in leukocytes.
Main Results:
- ROCK activity was significantly higher in type 2 diabetic patients (0.80±0.10 vs. 0.72±0.08, P<0.01).
- A positive correlation existed between ROCK activity and HbA1c in diabetic patients (r=0.40, P=0.01).
- Multiple regression confirmed ROCK activity's positive association with HbA1c in type 2 diabetes (β=0.03, P=0.04).
Conclusions:
- ROCK activity is significantly increased in type 2 diabetic patients.
- Enhanced ROCK activity may serve as an indicator of type 2 diabetes progression.
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