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Updated: Mar 15, 2026
T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
Published on: January 12, 2021
ImmuneDB: a system for the analysis and exploration of high-throughput adaptive immune receptor sequencing data
Aaron M Rosenfeld1, Wenzhao Meng2, Eline T Luning Prak2
1School of Biomedical Engineering Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA.
Abstract:
As high-throughput sequencing of B cells becomes more common, the need for tools to analyze the large quantity of data also increases. This article introduces ImmuneDB, a system for analyzing vast amounts of heavy chain variable region sequences and exploring the resulting data. It can take as input raw FASTA/FASTQ data, identify genes, determine clones, construct lineages, as well as provide information such as selection pressure and mutation analysis. It uses an industry leading database, MySQL, to provide fast analysis and avoid the complexities of using error prone flat-files.
Availability And Implementation:
ImmuneDB is freely available at http://immunedb.comA demo of the ImmuneDB web interface is available at: http://immunedb.com/demo CONTACT: Uh25@drexel.eduSupplementary information: Supplementary data are available at Bioinformatics online.
