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Acute amitriptyline effects on parasympathetic-evoked rat saliva
Neuropsychobiology
|January 1, 1989
Summary
Amitriptyline, a common antidepressant, was found to decrease salivary secretion in rats by blocking cholinergic receptors, similar to atropine. This study investigated its acute effects on parasympathetic-stimulated saliva.
Area of Science:
- Pharmacology
- Neuroscience
- Salivary Gland Physiology
Background:
- Amitriptyline is a tricyclic antidepressant with known anticholinergic properties.
- Parasympathetic stimulation is the primary driver of salivary secretion.
- Understanding drug effects on salivary function is crucial for managing side effects.
Purpose of the Study:
- To investigate the acute effects of amitriptyline on parasympathetic-evoked salivary secretion in rats.
- To determine the impact of amitriptyline on salivary flow rate and electrolyte concentrations.
Main Methods:
- Rats underwent electrical stimulation of parasympathetic innervations to salivary glands.
- Single intravenous injections of amitriptyline (0.1-1 mg/kg) were administered.
- Saliva flow rate, sodium (Na), potassium (K), calcium (Ca), protein concentration, and amylase activity were analyzed.
Main Results:
- Amitriptyline caused a dose-dependent decrease in salivary flow and Na concentration in both parotid and submandibular glands.
- Increased Ca concentration in submandibular saliva and protein concentration in both gland types were observed.
- Amylase activity in parotid saliva was moderately increased, mimicking atropine's effects.
Conclusions:
- Amitriptyline reduces parasympathetic-evoked salivary secretion.
- These effects are attributed to the blockade of cholinergic receptors, similar to atropine.
- The findings highlight amitriptyline's anticholinergic impact on salivary gland function.
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