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Causality of small and large intestinal microbiota in weight regulation and insulin resistance

Torsten P M Scheithauer1, Geesje M Dallinga-Thie2, Willem M de Vos3

  • 1Department of Vascular Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands; Diabetes Center, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands; Institute for Cardiovascular Research (ICaR), VU University Medical Center, Amsterdam, The Netherlands.

Molecular Metabolism
|September 13, 2016
PubMed
Abstract

Keywords:
16s rRNA, 16S ribosomal RNA (30S small subunit of prokaryotic ribosomes)AMP, adenosine monophosphateAMPK, AMP-activated protein kinaseAS160, Akt substrate of 160 kDaAngptl4, Angiopoietin-like 4CB1R, cannabinoid receptor type 1CCL2, Chemokine (C–C motif) ligand 2DIO, diet-induced obesityDiabetesGF, germ-freeGLP, glucagon-like peptideGpr, G-protein coupled receptorGut microbiotaHFD, high fat dietIL, interleukinIRS-1, insulin receptor substrate 1Insulin resistanceJNK, C-Jun N-terminal kinaseLBP, LPS-binding proteinLPL, lipoprotein lipaseLPS, lipopolysaccharideMCP-1, monocyte chemotactic protein 1NOD1, nucleotide-binding oligomerization domain-containing protein 1ObesityPKB, protein kinase B (also known as Akt)PYY, peptide YY (for tyrosine–tyrosine)RYGB, Roux-en-Y gastric bypassSCFA, short-chain fatty acidT2D, Type 2 diabetes mellitusTLR, toll-like receptorTNF-α, tumor necrosis factor alphaVLDL, very low density lipoproteinWHO, World Health OrganizationWeight regulationZO, zonula occludens

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