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Related Experiment Video

Updated: Mar 15, 2026

Use of the Scissor-Type Knife During the Peroral Endoscopy Myotomy Procedure for the Treatment of Achalasia
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Peroral endoscopic myotomy: a meta-analysis.

Emmanuel Akintoye1, Nitin Kumar2, Itegbemie Obaitan3

  • 1Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, United States.

Endoscopy
|September 13, 2016
PubMed
Summary

Peroral endoscopic myotomy (POEM) is a safe and effective treatment for achalasia and other esophageal motility disorders. This minimally invasive technique shows high success rates and significant symptom improvement in patients.

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Area of Science:

  • Gastroenterology
  • Minimally Invasive Surgery
  • Endoscopy

Background:

  • Peroral endoscopic myotomy (POEM) is an emerging minimally invasive endoscopic technique.
  • It is utilized for treating achalasia and other esophageal motility disorders.
  • Evaluating the safety and efficacy of POEM is crucial for clinical practice.

Purpose of the Study:

  • To systematically review and meta-analyze the existing medical literature on POEM.
  • To assess the clinical outcomes, safety, and efficacy of POEM in patients with esophageal motility disorders.

Main Methods:

  • A comprehensive literature search was conducted across five databases (MEDLINE, EMBASE, Ovid, CINAHL, Cochrane).
  • Studies published up to March 2016 reporting on POEM clinical outcomes were included.
  • A meta-analysis was performed on data from 36 studies involving 2373 patients.

Main Results:

  • POEM achieved a clinical success rate of 98% (Eckardt score ≤ 3).
  • Mean Eckardt scores significantly decreased post-procedure, indicating symptom relief.
  • Post-procedure, significant reductions were observed in lower esophageal sphincter pressure and integrated relaxation pressure.

Conclusions:

  • POEM demonstrates a favorable safety and efficacy profile based on current evidence.
  • The procedure leads to significant improvements in patient-reported symptoms and objective manometric parameters.
  • POEM is a viable first-line therapy option for achalasia and related disorders when performed by experienced endoscopists.