Related Experiment Videos
Functional activity patterns in the forebrain of swimming rats: a 5 min 2-deoxyglucose study
G E Duncan1, W E Stumpf, G R Breese
1Department of Cell Biology and Anatomy, School of Medicine, University of North Carolina, Chapel Hill 27599.
Abstract:
Effects of 5 min of swimming on functional activity patterns in the rat forebrain were examined by high resolution autoradiographic assessment of [14C]2-deoxyglucose ([14C]2-DG) uptake. In autoradiograms made from swimming rats, the isocortex displayed a columnar pattern in which columns of high optical density, oriented perpendicularly to the cortical surface, were separated by columns of low optical density of similar orientation. Increased [14C]2-DG uptake in swimming rats compared to resting rats was also apparent in the lateral septal nucleus, globus pallidus, and endopiriform nucleus. The results demonstrate that 2-DG can be used in short survival uptake experiments to gain insight into neuroanatomical patterns of functional activity.