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Cryptococcal cellulitis on the shin of an immunosuppressed patient
Tian Hao Zhu, Paola G Rodriguez, James W Behan
1Departments of Dermatology University of Southern California Keck School of Medicine, Los Angeles, California. genekim@usc.edu.
Abstract:
Cryptococcus neoformans is a common fungus found throughout the environment that causes opportunistic disease in immunocompromised individuals. Infection of humans with C neoformans usually manifests as lung disease through inhalation of spores or meningoencephalitis by involvement of the central nervous system. Rarely, dissemination in the form of cutaneous lesions can occur in individuals with long term immunosuppression. We present a patient with C. neoformans manifesting as cellulitis with focal segmental glomerulosclerosis treated with corticosteroids. Because of the mortality associated with disseminated cryptococcosis, early identification, especially of atypical cutaneous presentations is critical from a dermatological perspective.
Insights
Cryptococcus neoformans, a common fungus, can cause rare skin lesions in immunocompromised patients. Early identification of these atypical cutaneous presentations is crucial for effective treatment and improved outcomes.
Area of Science:
- Mycology
- Infectious Diseases
- Dermatology
Background:
- Cryptococcus neoformans is an environmental fungus.
- It typically causes lung disease or meningoencephalitis in immunocompromised individuals.
- Disseminated cutaneous cryptococcosis is a rare manifestation.
Observation:
- A case of Cryptococcus neoformans presenting as cellulitis is described.
- The patient had focal segmental glomerulosclerosis and was treated with corticosteroids.
- This highlights an atypical cutaneous presentation of the infection.
Findings:
- The study presents a rare case of disseminated cryptococcosis.
- The manifestation was atypical, appearing as cellulitis rather than typical pulmonary or CNS disease.
- This case underscores the importance of considering fungal infections in unusual presentations.
Implications:
- Early diagnosis of atypical cutaneous cryptococcosis is critical.
- Dermatologists should be aware of rare fungal infections.
- Prompt identification can improve patient prognosis and reduce mortality associated with disseminated disease.
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