Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vision01:24

Vision

61.2K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
61.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activity in serotonergic axons in visuomotor areas of cortex is modulated by the recent history of visuomotor coupling.

Peer community journal·2025
Same author

Pupil size modulation drives retinal activity in mice and shapes human perception.

Nature communications·2025
Same author

Multimodal mismatch responses in mouse auditory cortex.

eLife·2025
Same author

Cholinergic input to mouse visual cortex signals a movement state and acutely enhances layer 5 responsiveness.

eLife·2024
Same author

Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers.

eLife·2024
Same author

Molecularly targetable cell types in mouse visual cortex have distinguishable prediction error responses.

Neuron·2023

Related Experiment Video

Updated: Mar 15, 2026

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
08:42

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex

Published on: February 8, 2020

11.4K

Experience-dependent spatial expectations in mouse visual cortex.

Aris Fiser1,2, David Mahringer1,2, Hassana K Oyibo1,2

  • 1Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

Nature Neuroscience
|November 8, 2016
PubMed
Summary
This summary is machine-generated.

Neurons in the mouse visual cortex (V1) learn to predict upcoming visual stimuli based on spatial location. This internal predictive model influences sensory processing and involves the anterior cingulate cortex.

More Related Videos

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice
08:59

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice

Published on: March 3, 2023

3.0K
Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging
06:18

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Published on: November 21, 2023

1.4K

Related Experiment Videos

Last Updated: Mar 15, 2026

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
08:42

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex

Published on: February 8, 2020

11.4K
An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice
08:59

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice

Published on: March 3, 2023

3.0K
Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging
06:18

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Published on: November 21, 2023

1.4K

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Sensory Processing

Background:

  • Generative models of brain function propose internal representations predict sensory input.
  • The influence of these internal models on sensory processing remains poorly understood.
  • Investigating the neural basis of predictive coding in the visual system is crucial.

Purpose of the Study:

  • To investigate how internal models influence sensory processing in the primary visual cortex (V1).
  • To determine if neuronal activity in V1 becomes spatially informative with experience.
  • To explore the role of anterior cingulate cortex (ACC) in generating predictions for V1.

Main Methods:

  • Utilized a virtual environment to train mice and record neuronal activity in layer 2/3 of V1.
  • Analyzed neuronal responses for spatial information and predictive coding.
  • Examined activity in V1-projecting anterior cingulate cortex (ACC) axons.

Main Results:

  • Neuronal activity in mouse V1 became increasingly informative of spatial location with virtual environment experience.
  • A subset of V1 neurons showed spatially dependent responses predictive of upcoming visual stimuli.
  • Omission of expected stimuli elicited strong responses in V1, and predictive responses were observed in ACC axons projecting to V1.

Conclusions:

  • Experience shapes internal models in V1, leading to spatially predictive neuronal activity.
  • The anterior cingulate cortex appears to be a source of top-down predictions for the visual cortex.
  • Findings support a model where V1 compares internal spatial representations with incoming visual information.