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Full dose subcutaneous heparin therapy.

G Hollander, R Rothenberg, A Greengart

    New York State Journal of Medicine
    |July 1, 1989
    PubMed
    Summary
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    Subcutaneous heparin offers a safe and effective alternative to continuous intravenous infusions for anticoagulation in myocardial infarction patients. This method reduces complications and provides significant cost savings.

    Area of Science:

    • Cardiology
    • Pharmacology
    • Health Economics

    Background:

    • Anticoagulation is crucial for managing thromboembolic disorders.
    • Continuous intravenous heparin infusion is standard but poses challenges.
    • Subcutaneous heparin presents a potential alternative for full-dose anticoagulation.

    Purpose of the Study:

    • To evaluate the safety and efficacy of full-dose subcutaneous heparin.
    • To assess the cost-effectiveness of subcutaneous versus intravenous heparin administration.

    Main Methods:

    • A study involving fifteen hospitalized myocardial infarction patients.
    • Transitioning patients from continuous intravenous heparin to subcutaneous heparin therapy.
    • Monitoring for complications and comparing administration routes.

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    Main Results:

    • Subcutaneous heparin administration was associated with minimal complications, primarily local hematomas.
    • Therapeutic anticoagulation was successfully maintained via the subcutaneous route.
    • Significant cost reductions were observed with subcutaneous heparin administration compared to intravenous therapy.

    Conclusions:

    • Full-dose subcutaneous heparin is a safe and effective method for anticoagulation in myocardial infarction patients.
    • This administration route offers a more convenient and cost-effective alternative to continuous intravenous infusions.
    • Subcutaneous heparin warrants consideration for routine clinical practice in relevant patient populations.