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Evaluation of vitamin D levels in children with primary epistaxis

Habip Almis1, Ibrahim Hakan Bucak1, Muhammed Nebi Caliskan1

  • 1Adiyaman University, School of Medicine, Department of Pediatrics, Adiyaman, Turkey.

International Journal of Pediatric Otorhinolaryngology
|September 14, 2016
PubMed

Insights

Children with primary epistaxis have lower 25-hydroxy vitamin D levels. Maintaining adequate vitamin D may help prevent nosebleeds in children.

Area of Science:

  • Pediatric Medicine
  • Nutritional Science
  • Otolaryngology

Background:

  • Primary epistaxis is a common condition in children.
  • Vitamin D plays a role in immune function and inflammation.
  • The relationship between vitamin D status and epistaxis is not well-established.

Purpose of the Study:

  • To investigate the association between 25-hydroxy vitamin D [25(OH)D3] levels and the incidence of primary epistaxis in children.

Main Methods:

  • A case-control study involving 42 children with primary epistaxis and 55 matched controls.
  • Recorded demographic data, coagulation parameters (APTT, INR, PT), and serum levels of 25(OH)D3, PTH, ALP, Ca, Mg, and P.
  • Utilized univariate and multivariate logistic regression analyses to identify significant predictors.

Main Results:

  • Children with primary epistaxis had significantly lower serum 25(OH)D3 levels compared to controls (P=0.03).
  • Lower 25(OH)D3 levels were also observed in children with epistaxis and upper respiratory tract infections (RTI).
  • 25(OH)D3 levels below 20 ng/ml and serum albumin levels were significantly associated with primary epistaxis (ORs ranging from 1.117 to 3.499).

Conclusions:

  • Vitamin D status may be a significant factor in the prevention of childhood primary epistaxis.
  • The findings suggest a potential role for vitamin D supplementation in managing or preventing epistaxis.
  • Further research is needed to confirm these findings and elucidate the underlying mechanisms.
Abstract

Keywords:
25 hydroxy vitamin DChildEpistaxisInfection

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