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Updated: Mar 15, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
Published on: May 18, 2020
Modeling estrogen receptor-positive breast cancers in mice: is it the best we can do?
Ioulia Chatzistamou1, Hippokratis Kiaris2
1Department of PathologyMicrobiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Abstract:
The continuous supplementation of mice with supraphysiological doses of estrogen for the growth of estrogen receptor-positive breast cancers has been linked to toxicity in the host and perturbation of cancer cells' function that can misguide preclinical studies. Thus, alternative experimental models with circulating levels of estrogens higher than those of mice may represent more suitable hosts to model estrogen receptor-positive breast cancers.

