Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lysosomal Hydrolases01:22

Lysosomal Hydrolases

4.7K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
4.7K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.3K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.3K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.3K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.3K
Neural Regulation01:37

Neural Regulation

44.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
44.0K
The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

5.1K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
5.1K
ER Retrieval Pathway01:45

ER Retrieval Pathway

5.0K
In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TorsinA is essential for neuronal nuclear pore complex localization and maturation.

Nature cell biology·2024
Same author

Dynamic regulation of hepatic lipid metabolism by torsinA and its activators.

JCI insight·2024
Same author

Functional interaction of torsinA and its activators in liver lipid metabolism.

bioRxiv : the preprint server for biology·2023
Same author

TorsinA is essential for the timing and localization of neuronal nuclear pore complex biogenesis.

bioRxiv : the preprint server for biology·2023
Same author

Genetic evidence of aberrant striatal synaptic maturation and secretory pathway alteration in a dystonia mouse model.

Dystonia (Lausanne, Switzerland)·2023
Same author

Hepatocytes Deficient in Nuclear Envelope Protein Lamina-associated Polypeptide 1 are an Ideal Mammalian System to Study Intranuclear Lipid Droplets.

Journal of lipid research·2022

Related Experiment Video

Updated: Mar 15, 2026

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
06:07

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

2.4K

Endolysosomal dysfunction in Parkinson's disease: Recent developments and future challenges.

Lauren R Kett1,2, William T Dauer3,4

  • 1Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Movement Disorders : Official Journal of the Movement Disorder Society
|September 14, 2016
PubMed
Summary
This summary is machine-generated.

Endolysosomal system dysfunction is increasingly linked to Parkinson's disease (PD). A new mouse model lacking the Atp13a2 protein reveals mechanisms connecting endolysosomal issues to PD pathogenesis and alpha-synuclein toxicity.

Keywords:
Atp13a2Kufor-Rakeb syndromeParkinson's diseaseendolysosomal system

More Related Videos

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
07:46

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

12.7K
The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

17.5K

Related Experiment Videos

Last Updated: Mar 15, 2026

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
06:07

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

2.4K
Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
07:46

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

12.7K
The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

17.5K

Area of Science:

  • Neuroscience
  • Genetics
  • Cell Biology

Background:

  • Endolysosomal system dysfunction is implicated in Parkinson's disease (PD) pathogenesis.
  • Mechanisms linking endolysosomal dysfunction to PD and alpha-synuclein toxicity require further investigation.

Purpose of the Study:

  • To revisit evidence linking the endolysosomal system to PD.
  • To discuss current hypotheses of PD pathogenesis.
  • To explore how recent studies refine these hypotheses and identify future research questions.

Main Methods:

  • Utilized a novel mouse model with a loss-of-function mutation in the endolysosomal protein Atp13a2.
  • Observed behavioral, neuropathological, and biochemical changes in the mouse model.
  • Reviewed existing literature on endolysosomal system dysfunction and PD.

Main Results:

  • The Atp13a2-deficient mouse model exhibits parkinsonism-like features.
  • These features include behavioral deficits, neuropathology, and biochemical alterations mirroring human PD.
  • The model provides a platform to study the interplay between endolysosomal dysfunction and alpha-synuclein.

Conclusions:

  • Primary endolysosomal dysfunction is a significant contributor to PD.
  • The Atp13a2 protein plays a crucial role in maintaining endolysosomal function and preventing PD pathology.
  • Further research is needed to fully elucidate the complex mechanisms involved in PD pathogenesis.