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Metabolic interactions with cancer epigenetics

Xia Gao1, Michael A Reid2, Mei Kong2

  • 1Department of Pharmacology and Cancer Biology, Duke Cancer Institute, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA.

Molecular Aspects of Medicine
|September 14, 2016
PubMed

Insights

Cancer cells possess reversible epigenetic alterations that can be targeted for therapy. This review explores the crucial interplay between cancer metabolism and epigenetics, highlighting therapeutic opportunities.

Area of Science:

  • Oncology
  • Epigenetics
  • Cancer Metabolism

Background:

  • Epigenetic alterations are hallmarks of cancer, driving disease progression.
  • The reversible nature of epigenetic modifications presents a promising therapeutic avenue.
  • Cellular metabolism significantly influences and interacts with epigenetic status in cancer.

Purpose of the Study:

  • To review recent advancements in understanding the crosstalk between cancer metabolism and epigenetics.
  • To identify therapeutic vulnerabilities arising from this metabolic-epigenetic nexus.

Main Methods:

  • Literature review of recent studies on cancer metabolism and epigenetics.
  • Analysis of the biological contexts mediating the interaction between metabolism and epigenetics.

Main Results:

  • Epigenetic modifications are dynamically regulated by cellular metabolic pathways.
  • Metabolic reprogramming in cancer cells creates unique dependencies on epigenetic machinery.
  • Targeting the metabolic-epigenetic interface offers novel strategies for cancer treatment.

Conclusions:

  • The interaction between cancer metabolism and epigenetics is a critical determinant of cancer progression and vulnerability.
  • Exploiting this nexus holds significant potential for developing innovative cancer therapies.
  • Further research into this interplay is essential for advancing cancer treatment strategies.
Keywords:
Acetyl-CoAMethionineOne-carbon metabolismS-Adenosyl methionineSerineα-Ketoglutarate

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