Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Host predisposition to trichuriasis: the mouse--T. muris model.

K J Else1, D Wakelin, T I Roach

  • 1Department of Zoology, University of Nottingham, University Park.

Parasitology
|April 1, 1989
PubMed
Summary

Poorly responding mice cannot clear Trichuris worms due to a long-lasting immune defect. Larval persistence beyond 21 days critically impacts reinfection susceptibility in trichuriasis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antibodies and Inflammation: Fecal Biomarkers of Gut Health in Domestic Ruminants.

Journal of experimental zoology. Part A, Ecological and integrative physiology·2025
Same author

Lessons from studying roundworm and whipworm in the mouse: common themes and unique features.

Parasitology·2021
Same author

Caveolin1 interacts with the glucocorticoid receptor in the lung but is dispensable for its anti-inflammatory actions in lung inflammation and Trichuris Muris infection.

Scientific reports·2019
Same author

Stability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation.

Scientific reports·2017
Same author

Anti-inflammatory effects of infliximab in mice are independent of tumour necrosis factor α neutralization.

Clinical and experimental immunology·2016
Same author

Antigens yield to new technology.

Immunology today·2014

Area of Science:

  • Immunology
  • Parasitology
  • Helminthology

Background:

  • Trichuriasis susceptibility varies in mice, with some strains unable to develop protective immunity.
  • Poor responders fail to expel worms, leading to chronic infections.

Purpose of the Study:

  • Investigate mechanisms of non-responsiveness to Trichuris infection in mice.
  • Determine factors influencing susceptibility to primary and secondary infections.

Main Methods:

  • Challenging poor responder mice with Trichuris after abbreviated or prolonged primary infections.
  • Assessing worm expulsion and infection chronicity.
  • Analyzing serological responses, including antibody titers and antigen recognition.

Main Results:

  • Mice failing to expel primary infections remained susceptible to challenge infections.
  • Persistence of Trichuris larvae beyond 21 days was critical for poor response to reinfection.
  • Low antibody titers and restricted antigen recognition correlated with poor resistance.

Conclusions:

  • Non-responsiveness to Trichuris infection is a long-lasting immune defect, not related to worm size or immune response speed.
  • Later stages of parasite development may exert immunosuppressive effects.
  • Findings offer insights into human trichuriasis pathogenesis and immune evasion strategies.

Related Experiment Videos