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In Vitro Activity of Solithromycin against Bordetella pertussis, an Emerging Respiratory Pathogen

Dwight J Hardy1, David Vicino2, Prabhavathi Fernandes3

  • 1Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA Dwight_Hardy@urmc.rochester.edu.

Antimicrobial Agents and Chemotherapy
|September 14, 2016
PubMed

Insights

Pertussis cases are rising, and adults often have undiagnosed coughs. New solithromycin shows potent in vitro activity against Bordetella pertussis, offering a potential new treatment option.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Pertussis (whooping cough) incidence is increasing, particularly in vaccinated populations.
  • Adult pertussis cases often present as persistent, nonspecific coughs, leading to underdiagnosis.
  • Current treatment relies on macrolide antibiotics like azithromycin.

Purpose of the Study:

  • To evaluate the in vitro activity of solithromycin, a novel fluoroketolide antibiotic, against recent Bordetella pertussis isolates.

Main Methods:

  • In vitro susceptibility testing of solithromycin against clinical isolates of Bordetella pertussis.

Main Results:

  • Solithromycin demonstrated potent in vitro activity against the tested Bordetella pertussis isolates.
  • This activity suggests potential efficacy against the causative agent of pertussis.

Conclusions:

  • Solithromycin exhibits promising in vitro activity against Bordetella pertussis.
  • Further investigation into solithromycin as a treatment for pertussis is warranted.

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