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Optical coherence tomography attenuation imaging for lipid core detection: an ex-vivo validation study
Muthukaruppan Gnanadesigan1, Ali S Hussain2, Stephen White3
1Department of Biomedical Engineering, Erasmus Medical Center, PO Box 2040, 3000, Rotterdam, CA, The Netherlands.
The International Journal of Cardiovascular Imaging
|September 14, 2016
Summary
Quantitative attenuation in intravascular optical coherence tomography (OCT) accurately measures coronary plaque lipid. This new index of plaque attenuation (IPA) offers a robust, reproducible method for lipid quantification in clinical research and interventions.
Area of Science:
- Cardiovascular Imaging
- Biomedical Engineering
- Translational Medicine
Background:
- Lipid-core atherosclerotic plaques increase cardiovascular event risk.
- Current lipid quantification in optical coherence tomography (OCT) is labor-intensive and subjective.
- Accurate lipid detection is crucial for managing atherosclerotic disease.
Purpose of the Study:
- To evaluate quantitative attenuation from intravascular OCT for detecting plaque lipid.
- To compare the index of plaque attenuation (IPA) with manual OCT lipid measurements and ex-vivo histology.
- To establish IPA as a reliable tool for coronary lipid quantification.
Main Methods:
- Intravascular OCT data was analyzed to derive the index of plaque attenuation (IPA).
- IPA was compared to manual measurements of lipid arc and length from OCT images.
- Ex-vivo histology was used to correlate high attenuation with plaque composition.
Main Results:
- A strong correlation (r² > 0.7) was confirmed between IPA and manual lipid scores.
- High attenuation, measured by IPA, correlated with fibroatheroma and macrophage presence.
- IPA demonstrated robustness, reproducibility, and user independence.
Conclusions:
- Quantitative attenuation via IPA is a reliable method for assessing coronary plaque lipid.
- IPA offers a user-independent and reproducible alternative to manual lipid quantification.
- IPA shows potential as a valuable tool in cardiovascular research and percutaneous coronary intervention guidance.
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