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Acute ascorbic acid infusion increases left ventricular diastolic function in postmenopausal women.

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Oxidative stress impairs left ventricular diastolic function in postmenopausal women by reducing nitric oxide (NO) bioavailability. Ascorbic acid improved NO bioavailability and diastolic function in these women.

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Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Oxidative Stress Research

Background:

  • Estrogen deficiency in postmenopausal women is associated with impaired cardiovascular function.
  • Oxidative stress and reduced nitric oxide (NO) bioavailability are implicated in cardiovascular disease.
  • Left ventricular diastolic dysfunction is a key indicator of cardiac health.

Purpose of the Study:

  • To investigate the role of oxidative stress in reduced left ventricular diastolic function in postmenopausal women.
  • To determine if reduced nitric oxide (NO) bioavailability mediates this effect.
  • To assess the impact of reducing oxidative stress on diastolic function and NO bioavailability.

Main Methods:

  • Transthoracic echocardiography was used to measure left ventricular (LV) diastolic function (E/A and E/e' ratios).
  • Brachial artery flow-mediated dilation (FMD) was measured as a biomarker of NO bioavailability.
  • Saline (control) and ascorbic acid (to decrease oxidative stress) were infused in premenopausal and postmenopausal women.

Main Results:

  • Postmenopausal women exhibited reduced LV diastolic function (lower E/A, higher E/e') compared to premenopausal women.
  • LV diastolic function parameters correlated with FMD, indicating a link with NO bioavailability.
  • Ascorbic acid improved FMD and E/e' in postmenopausal women, but not E/A, suggesting partial restoration of function.

Conclusions:

  • Oxidative stress contributes to reduced LV diastolic function in estrogen-deficient postmenopausal women.
  • Reduced nitric oxide (NO) bioavailability is a likely mechanism linking oxidative stress to diastolic dysfunction.
  • Targeting oxidative stress may offer a therapeutic strategy for improving cardiac function in postmenopausal women.