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Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells
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E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity

Matthieu Lacroix1, Geneviève Rodier2, Olivier Kirsh3

  • 1Institut de Recherche en Cancérologie de Montpellier, Montpellier F-34298, France; INSERM, U1194, Montpellier F-34298, France; Université Montpellier, Montpellier F-34090, France; Institut du Cancer Montpellier, Montpellier F-34298, France; Equipe labellisée Ligue Contre le Cancer, 75013 Paris, France;

Proceedings of the National Academy of Sciences of the United States of America
|September 14, 2016
PubMed
Summary

The transcription factor E4F1 is a master regulator of the pyruvate dehydrogenase complex (PDC), controlling key genes for pyruvate oxidation. E4F1 dysfunction causes severe metabolic defects, mimicking symptoms in patients with PDC deficiencies.

Keywords:
E4F1PDHendurancemusclepyruvate

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