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Vascular endothelial growth factor and hypoxia-inducible factor-1α gene polymorphisms and coronary collateral

Vincent Amoah1, Benjamin Wrigley1, Eric Holroyd1

  • 1Department of Cardiology, Heart and Lung Centre, New Cross Hospital, Wolverhampton, UK.

SAGE Open Medicine
|September 14, 2016
PubMed

Insights

Genetic variations in vascular endothelial growth factor and hypoxia-inducible factor-1α were not linked to coronary collateral formation in patients with chronic total occlusion. However, prior interventions and stroke history showed associations with enhanced collateral vessel development.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Cardiology

Background:

  • Coronary chronic total occlusion (CTO) presents a significant clinical challenge.
  • Coronary collateral circulation plays a crucial role in mitigating ischemia in CTO patients.
  • Genetic factors influencing collateral formation are of great interest.

Purpose of the Study:

  • To investigate the association between specific genetic polymorphisms in vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α) and the degree of coronary collateral formation in patients with CTO.
  • To explore potential genetic markers for predicting collateral development in coronary artery disease.

Main Methods:

  • A cohort of 98 patients with symptomatic coronary artery disease and CTO was recruited.
  • Genotyping was performed for VEGF promoter polymorphisms (-152G>A, -165C>T) and HIF-1α C1772T using PCR-RFLP.
  • Coronary collateral vessel filling was assessed and graded by blinded observers using the Rentrop grade.

Main Results:

  • No significant association was found between the tested VEGF and HIF-1α single nucleotide polymorphisms and the presence or extent of coronary collateral vessels.
  • Binary logistic regression analysis revealed that a history of percutaneous coronary intervention and transient ischemic attack/cerebrovascular accident were associated with enhanced collateral vessel formation.

Conclusions:

  • The studied polymorphic variants of VEGF and HIF-1α do not appear to be associated with coronary collateral formation in patients with symptomatic coronary artery disease and CTO.
  • Factors such as prior revascularization procedures and cerebrovascular events may influence collateral development in this patient population.
Abstract

Keywords:
CardiovascularRentrop gradechronic total occlusiongene polymorphismhypoxia-inducible factor-1αpolymerase chain reactionvascular endothelial growth factor

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