Comparison of left ventricular ejection fraction values obtained using invasive contrast left ventriculography,...

Area of Science:

• Cardiology
• Medical Imaging
• Diagnostic Techniques

Background:

• Left ventricular ejection fraction (LVEF) is a critical indicator of cardiac function.
• Multiple imaging modalities exist for LVEF assessment, including invasive and non-invasive methods.

Purpose of the Study:

• To compare the correlation of LVEF measurements obtained from invasive contrast left ventriculography, two-dimensional echocardiography, and quantitative gated single-photon emission computed tomography.
• To evaluate the inter-modality agreement for LVEF assessment.

Main Methods:

• Retrospective chart review of 58 patients hospitalized with chest pain.
• Patients underwent LVEF evaluation using invasive contrast left ventriculography, 2D echocardiography, and gated SPECT within a 3-month period.
• Analysis of correlation coefficients and p-values between the three modalities.

Main Results:

• Mean LVEF values: invasive ventriculography (0.44±0.15), 2D echocardiography (0.46±0.13), and gated SPECT (0.37±0.10).
• Strong positive correlations were observed: invasive ventriculography vs. 2D echocardiography (r=0.69, p<0.001); invasive ventriculography vs. gated SPECT (r=0.80, p<0.0001); gated SPECT vs. 2D echocardiography (r=0.69, p<0.001).

Conclusions:

• Significant positive correlations exist among invasive contrast left ventriculography, two-dimensional echocardiography, and gated single-photon emission computed tomography for LVEF measurement.
• These findings suggest good inter-modality agreement for assessing left ventricular ejection fraction.