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Related Experiment Videos

Modification of gelatin beadlets for zero-order sustained release.

C S Chiao1, J C Price

  • 1School of Pharmacy, Northeast Louisiana University, Monroe 71209.

Pharmaceutical Research
|June 1, 1989
PubMed
Summary

Gelatin beadlets containing succinylsulfathiazole were developed for sustained drug release. Coating with cellulose acetate butyrate significantly improved drug release profiles, achieving nearly zero-order kinetics in simulated intestinal fluid.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Gelatin beadlets are a common drug delivery system.
  • Controlling drug release rates is crucial for therapeutic efficacy.

Purpose of the Study:

  • To develop sustained-release gelatin beadlets for succinylsulfathiazole.
  • To investigate the impact of hardening and coating on drug release kinetics.

Main Methods:

  • Three-phase suspension process for beadlet preparation.
  • Formalin hardening of gelatin beadlets.
  • Emulsion-solvent evaporation for cellulose acetate butyrate (CAB) coating.

Main Results:

  • Formalin hardening for 6 hours yielded the slowest release rate.
  • CAB coating significantly enhanced sustained release and approached zero-order kinetics in simulated intestinal fluid (SIF).

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  • Gelatin swelling influenced the rupture of the CAB coating, affecting drug release.

    • Conclusions:

    • Formalin-hardened and CAB-coated gelatin beadlets offer improved sustained drug release.
    • Drug release can be modulated by adjusting gelatin and CAB ratios.
    • This formulation shows potential for controlled drug delivery applications.