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[The fibronectin level in children with diabetes mellitus]
Problemy Endokrinologii
|May 1, 1989
Insights
In pediatric patients with insulin-dependent diabetes mellitus, higher fibronectin levels indicate longer disease duration, severe decompensation, and microangiopathy presence. This finding aids in understanding diabetes complications in children.
Area of Science:
- Biochemistry
- Pediatric Endocrinology
- Immunology
Context:
- Investigating biomarkers for diabetic complications in children.
- Assessing the role of fibronectin in pediatric diabetes mellitus.
Purpose:
- To determine fibronectin levels in pediatric patients with insulin-dependent diabetes mellitus.
- To correlate fibronectin concentration with disease duration, severity, and microangiopathy.
Summary:
- Analyzed plasma fibronectin in 42 pediatric patients with insulin-dependent diabetes mellitus using an immunoturbidometric method.
- Found elevated fibronectin in patients with disease duration over 5 years, third-degree decompensation, and microangiopathy.
Impact:
- Highlights fibronectin as a potential indicator of advanced complications in pediatric diabetes.
- Informs clinical assessment and management strategies for pediatric diabetes mellitus.
Abstract:
A study was made of the level of fibronectin in 42 pediatric patients with insulin dependent diabetes mellitus. Blood plasma fibronectin was determined by an immunoturbidometric method. A raised concentration of fibronectin was established in patients with a period of disease over 5 yrs., in decompensation of 3rd degree, and the presence of microangiopathies.