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Is atherosclerosis increasing in Mexico City?

L Cueto-Garcia1, C Restrepo, M A Guzman

  • 1Instituto Nacional de Cardiologia Ignacio Chavez, Mexico.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|July 1, 1989
PubMed
Summary

Atherosclerosis in Mexico City men increased between 1960-1964 and 1986-1987, particularly in coronary arteries. Researchers found more advanced lesions in coronary arteries in the later period.

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Area of Science:

  • Cardiovascular Pathology
  • Epidemiology
  • Public Health

Background:

  • Atherosclerosis is a major cause of cardiovascular disease globally.
  • Understanding temporal trends in atherosclerosis extent is crucial for public health interventions.

Purpose of the Study:

  • To compare the quantitative measures of atherosclerosis in aortas and coronary arteries between two distinct time periods in Mexico City.
  • To determine if the extent of atherosclerosis has changed over time in this population.

Main Methods:

  • Autopsy data from deceased men in Mexico City from 1960-1964 and 1986-1987 were analyzed.
  • Three pathologists independently graded fatty streaks (FS), fibrous plaques (FP), calcified plaques (CA), and complicated lesions (CO).
  • Comparisons were made between the two time periods using quantitative measures of lesion extent.

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Main Results:

  • No significant difference in FS or advanced lesions was found in the aorta between the two periods.
  • More extensive FP and raised atherosclerotic lesions (RL) were observed in coronary arteries in younger age groups in 1986-1987 compared to 1960-1964.
  • Age-matched analyses confirmed increased FS in aortic segments and more extensive RL in coronary arteries in the more recent study.

Conclusions:

  • Findings suggest an increasing trend of atherosclerosis, especially in coronary arteries, in Mexico City.
  • Further research is needed to investigate potential changes in risk factors contributing to this observed increase.