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Updated: Mar 15, 2026

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically

Published on: September 9, 2015

A microfluidic device for antimicrobial susceptibility testing based on a broth dilution method.

Wen-Bin Lee¹, Chien-Yu Fu¹, Wen-Hsin Chang¹

¹Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, 30013 Taiwan.

Biosensors & Bioelectronics

|September 14, 2016

Summary

This summary is machine-generated.

A new microfluidic device automates antimicrobial susceptibility testing, accurately determining minimum inhibitory concentration (MIC). This innovation offers a simpler, faster alternative to traditional methods for clinical applications.

Keywords:

Antibiotics Antimicrobial resistance Antimicrobial susceptibility testing Broth dilution Microfluidics Minimum inhibitory concentration Vancomycin-resistant Enterococcus

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Last Updated: Mar 15, 2026

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Stress-induced Antibiotic Susceptibility Testing on a Chip

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Published on: January 8, 2014

Area of Science:

Microfluidics
Antimicrobial Resistance
Clinical Diagnostics

Background:

Antimicrobial resistance is a growing global health threat.
Current antimicrobial susceptibility testing methods are labor-intensive and require expertise.
Accurate determination of minimum inhibitory concentration (MIC) is crucial for effective treatment.

Purpose of the Study:

To develop a simple, automated microfluidic device for antimicrobial susceptibility testing.
To accurately determine the minimum inhibitory concentration (MIC) of antibiotics.
To provide a portable and reliable alternative to conventional testing methods.

Main Methods:

A novel microfluidic device was designed for automated broth dilution.
The device performed automated sample injection, transport, mixing, and serial dilutions.
Wild-type and vancomycin-resistant Enterococcus were tested on-chip with varying vancomycin concentrations.

Main Results:

The microfluidic device determined MIC values comparable to the commercial Etest®.
Automated on-chip processes, including dilutions, were completed within nine minutes.
The device demonstrated high flexibility, reliability, and portability.

Conclusions:

The developed microfluidic device offers a simplified and automated approach to antimicrobial susceptibility testing.
This technology has potential for clinical and point-of-care applications.
The device accurately determines MIC, addressing the challenge of antimicrobial resistance.