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Pain in Extrapyramidal Neurodegenerative Diseases
Shlomit Yust-Katz1, Ronly Hershkovitz, Tanya Gurevich
1*Department of Neurology, Movement Disorder Clinic, Rabin Medical Center, Beilinson Hospital, Petach Tikva ‡Movement Disorders Unit, Tel Aviv Sourasky Medical Center †Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
The Clinical Journal of Pain
|September 14, 2016
Summary
Pain significantly affects quality of life in Parkinson disease (PD) and Parkinson plus syndromes. Effective pain management may involve adjusting anti-Parkinson medications or using analgesics like NSAIDs and medical cannabis.
Area of Science:
- Neurology
- Pain Management
- Movement Disorders
Background:
- Pain is a frequent nonmotor symptom in Parkinson disease (PD) and Parkinson plus syndromes.
- This symptom substantially impacts patients' quality of life.
Purpose of the Study:
- To investigate the prevalence and characteristics of pain in PD and Parkinson plus syndromes.
- To assess patient use and response to pain medications.
Main Methods:
- A cohort of 371 patients (300 with PD, 71 with Parkinson plus syndromes) was studied.
- Data on clinical parameters and pain were collected via questionnaire.
- Disease severity was assessed using the Unified Parkinson Disease Rating Scale for PD patients.
Main Results:
- Pain was reported by 74% of patients, with higher prevalence in PD (80%) versus Parkinson plus syndromes (50%).
- Synucleinopathies showed higher pain prevalence (70%) than tauopathies (40%), with central pain being common in synucleinopathies.
- Only 48% of pain sufferers received pain medication; NSAIDs and medical cannabis were most effective.
Conclusions:
- Pain is highly prevalent in patients with PD and Parkinsonian plus syndromes.
- Pain relief is achievable through optimized anti-Parkinson therapies or specific pain medications.
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