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Published on: April 16, 2019
A newly developed silymarin nanoformulation as a potential antidiabetic agent in experimental diabetes
Yousra M El-Far1, Mahmoud M Zakaria2, Mahmoud M Gabr2
1Department of Clinical Biochemistry, Faculty of Pharmacy, Mansoura University, 35516, Egypt.
Aim:
This study aimed to develop a new stable nanoformulation of silymarin (SM) with optimum enhanced oral bioavailability and to evaluate its effect as well as mechanism of action as a superior antidiabetic agent over native SM using streptozotocin-induced diabetic rats.
Materials And Methods:
SM-loaded pluronic nanomicelles (SMnp) were prepared and fully characterized. Biochemical parameters were performed as well as histological, confocal and reverse-transcription polymerase chain reaction studies on pancreatic target tissues.
Results & Conclusion:
SMnp were found to improve significantly the antihyperglycemic, antioxidant and antihyperlipidemic properties as compared with native SM. In addition, SMnp was found to be a more efficient agent over SM in the management of diabetes and its associated complications due to its superior bioavailability in vivo, and the controlled release profile of SM. [Formula: see text].
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