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Updated: Mar 15, 2026

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Aspergillosis complicating a microwave ablation cavity.

Saurabh Singh1, Steven Bandula1, Jeremy Brown2

  • 1Interventional Oncology Service, University College London Hospital, London, UK.

BMJ Case Reports
|September 15, 2016
PubMed
Summary

Chemotherapy can lead to semi-invasive pulmonary aspergillosis in lung cavities formed by microwave ablation (MWA). These MWA-created cavities pose a risk for fungal infections, impacting treatment timing for metastatic lung disease.

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Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Oncology

Background:

  • Metastatic nerve sheath tumor treatment often involves chemotherapy and procedures like microwave ablation (MWA).
  • Lung cavities can persist after MWA for pulmonary metastases.
  • Pulmonary aspergillosis is a serious fungal infection, particularly in immunocompromised patients.

Observation:

  • A 55-year-old woman developed cough and dyspnea post-chemotherapy.
  • Imaging revealed an enlarged lung cavity with thickened walls and internal mass, consistent with fungal ball (aspergilloma).
  • Elevated Aspergillus-specific IgG levels confirmed fungal infection.

Findings:

  • The patient developed semi-invasive pulmonary aspergillosis and an aspergilloma in a pre-existing MWA-created lung cavity.

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  • Treatment with itraconazole led to symptom improvement and reduction in cavity size and wall thickness.
  • Persisting lung cavities post-MWA are identified as potential sites for aspergillosis.
  • Implications:

    • Lung cavities from MWA represent a potential nidus for fungal infections like aspergillosis.
    • This finding has implications for managing patients with metastatic lung disease undergoing MWA and chemotherapy.
    • Careful consideration of the timing of chemotherapy in relation to MWA procedures may be necessary to mitigate risks.