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Replicating Cardiovascular Condition-Birth Month Associations.

Li Li1,2, Mary Regina Boland3,4,5,6, Riccardo Miotto1,2

  • 1Dept of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1498, New York, NY 10029, USA.

Scientific Reports
|September 15, 2016
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Summary
This summary is machine-generated.

Independent replication confirms that cardiovascular disease risk is higher for individuals born in late winter or early spring. This study analyzed Electronic Health Records (EHR) to validate seasonal birth month effects on cardiovascular conditions.

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Area of Science:

  • Epidemiology
  • Cardiovascular Research
  • Genetics and Environmental Factors

Background:

  • Independent replication is crucial for validating findings from Electronic Health Records (EHR) studies.
  • Previous research suggests a potential link between birth month and long-term cardiovascular disease (CVD) risk.

Purpose of the Study:

  • To replicate and evaluate the association between seasonal birth effects and lifetime risk of cardiovascular conditions.
  • To assess if seasonal patterns identified at Mount Sinai Hospital (MSH) align with prior findings from Columbia University Medical Center.

Main Methods:

  • A Season-wide Association Study was conducted on 1,169,599 patients from MSH.
  • Phenome-wide associations between birth month and CVD were computed.
  • Seasonal patterns from MSH were compared with previously reported data.

Main Results:

  • Coronary arteriosclerosis, essential hypertension, angina, and pre-infarction syndrome demonstrated phenome-wide significance, with seasonal patterns consistent with prior reports.
  • Atrial fibrillation, cardiomyopathy, and chronic myocardial ischemia showed consistent patterns but did not reach phenome-wide significance.
  • A confirmed peak in CVD risk was observed for individuals born in late winter/early spring.

Conclusions:

  • Replication findings strengthen the evidence for a seasonal birth month effect on cardiovascular disease risk.
  • The study confirms that individuals born in late winter/early spring have an elevated CVD risk.
  • Further research is needed to elucidate the underlying environmental and developmental mechanisms driving this association.