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Updated: Mar 15, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Designs for phase I trials in ordered groups
Mark R Conaway1, Nolan A Wages1
1Division of Translational Research and Applied Statistics, Department of Public Health Sciences, The University of Virginia, 22908, CharlottesvilleVA, U.S.A.
Abstract:
We propose a new design for dose finding for cytotoxic agents in two ordered groups of patients. By ordered groups, we mean that prior to the study there is clinical information that would indicate that for a given dose one group would be more susceptible to toxicities than patients in the other group. The designs are evaluated relative to two previously proposed designs for ordered groups over a range of scenarios generated randomly from a family of dose-toxicity curves. Copyright © 2016 John Wiley & Sons, Ltd.
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