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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Articles linked to this work by shared authors, journal, and citation graph.

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[Outcome of the geriatric head and neck cancer patient].

HNO·2026
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Beyond the nose: hearing status in 70 patients with congenital choanal atresia.

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Lack of De-Intensification Models for Female Head and Neck Cancer Patients With Favorable Prognosis.

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[Establishment of a newborn hearing screening center in Baden-Württemberg, Germany].

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Choanal atresia repair in Germany â€" a comprehensive investigation of the current state of care.

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Related Experiment Video

Updated: Mar 15, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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[Immunotherapy for HNSCC : Quo vadis?].

J Döscher1, C-J Busch2, P J Schuler3

  • 1Klinik für Hals-Nasen-Ohrenheilkunde und Kopf-Hals-Chirurgie, Universitätsklinik Ulm, Frauensteige 12, 89070, Ulm, Deutschland. johannes.doescher@uniklinik-ulm.de.

HNO
|September 15, 2016
PubMed
Summary

Immunotherapy shows promise for head and neck cancers, but reliable biomarkers are needed. Future research focuses on new agents and combinations to personalize curative treatments.

Keywords:
BiomarkerCTLA-4Head and neck cancerImmune modulationPD-1 receptor

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Area of Science:

  • Oncology
  • Immunotherapy
  • Biomarker Research

Background:

  • Immunotherapy is a promising treatment for head and neck squamous cell carcinoma (HNSCC).
  • Current research is exploring immunotherapy for first-line and curative settings, beyond palliative care.
  • Existing biomarkers lack the reliability to accurately predict patient response to immunotherapy.

Purpose of the Study:

  • To investigate the future of immunotherapies in cancer treatment.
  • To identify promising upcoming studies and current research in biomarker development for immunotherapy.

Main Methods:

  • Literature review of promising upcoming clinical trials in immunotherapy.
  • Analysis of current research on biomarkers for predicting immunotherapy response.
  • Focus on novel immunotherapeutic strategies and combinations.

Main Results:

  • Biomarker research is a critical focus for advancing immunotherapy.
  • Numerous new immunotherapeutic agents are entering clinical trials.
  • Combinations of immunotherapy with chemotherapy, chemoradiotherapy, or other immune-modulating drugs are being explored.

Conclusions:

  • Personalizing cancer treatment requires identifying the most effective regimen for each patient.
  • Developing a panel of reliable biomarkers is crucial for predicting treatment response.
  • Reliable biomarkers will enable tailored immunotherapy strategies for improved patient outcomes.