Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.6K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K
Genetic Lingo01:11

Genetic Lingo

116.8K
Overview
116.8K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.9K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

2.8K
2.8K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

10.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
10.5K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.5K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Melbourne rapid field test: Usability and clinical promise.

Indian journal of ophthalmology·2026
Same author

Assessment of driving safety in non-professional drivers with moderate to severe glaucoma.

Indian journal of ophthalmology·2026
Same author

Commentary on: The role of gonioscopy-assisted transluminal trabeculotomy in a resource-stratified world.

Indian journal of ophthalmology·2026
Same author

Associations between ocular surface parameters, contrast sensitivity, and higher-order aberrations in computer vision syndrome.

Indian journal of ophthalmology·2025
Same author

Color vision and contrast sensitivity changes in patient with primary angle closure and primary angle closure glaucoma.

Oman journal of ophthalmology·2025
Same author

Weighted Quality of Life in Glaucoma Patients with Advanced Disease.

Journal of current glaucoma practice·2025
Same journal

A Patient Diagnosed with Mosaic Trisomy 18 Presenting New Symptoms: Diaphragmatic Relaxation and Cyclic Vomiting Syndrome. Updated Review of Mosaic Trisomy 18 Cases.

Journal of pediatric genetics·2024
Same journal

<i>CDKN1C</i> -Related Beckwith-Wiedemann Syndrome: First Patient from India.

Journal of pediatric genetics·2024
Same journal

Understanding the Endocrine and Molecular Signaling Cascade Regulation Pathways in Children with Hypospadias.

Journal of pediatric genetics·2024
Same journal

Novel Case of Prader-Willi Syndrome and Ebstein's Anomaly: Implications for Complex Care Management.

Journal of pediatric genetics·2024
Same journal

Neonatal Onset Distal Renal Tubular Acidosis: Description of Two Novel Variants on the <i>ATP6V0A4</i> Gene and Review of the Literature on Associated Extrarenal Manifestations.

Journal of pediatric genetics·2024
Same journal

<i>LPL</i> Gene Mutation in Type 1 Familial Triglyceridemia Presenting as Recurrent Pancreatitis and Complicated by COVID19.

Journal of pediatric genetics·2024
See all related articles

Related Experiment Video

Updated: Mar 15, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

2.0K

Pediatric genetic diseases causing glaucoma.

Parul Ichhpujani1, Rohan B Singh1

  • 1Glaucoma Service, Department of Ophthalmology, Government Medical College and Hospital, Chandigarh, India.

Journal of Pediatric Genetics
|September 15, 2016
PubMed
Summary
This summary is machine-generated.

Genetic factors significantly influence glaucomatous optic neuropathy in children and adolescents. Understanding these inherited disorders is crucial for comprehensive glaucoma management beyond intraocular pressure reduction.

Keywords:
Axenfeld-Reiger syndromeMarfan syndromeRubinstein-Taybi syndromeSturge-Weber syndromeaniridiachildhood glaucomacongenital rubellaneurofibromatosis type 1nevus of Ota

More Related Videos

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

10.0K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.7K

Related Experiment Videos

Last Updated: Mar 15, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

2.0K
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

10.0K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.7K

Area of Science:

  • Ophthalmology
  • Genetics
  • Pediatrics

Background:

  • Glaucomatous optic neuropathy can result from various systemic factors.
  • Several genetic conditions are known to cause glaucoma in pediatric populations, including Axenfeld-Reiger syndrome, aniridia, Marfan syndrome, and neurofibromatosis type 1.

Purpose of the Study:

  • To highlight the role of systemic factors and genetic conditions in pediatric glaucoma.
  • To emphasize the importance of recognizing associated systemic diseases in glaucoma management.

Main Methods:

  • Review of literature on genetic causes of glaucoma in children and adolescents.
  • Analysis of advancements in genetic research related to inherited glaucoma disorders.

Main Results:

  • Genetic research has improved the understanding of fundamental causes of glaucoma in inherited disorders.
  • Multiple systemic associations exist with glaucoma, requiring clinical awareness.

Conclusions:

  • Effective glaucoma management requires addressing systemic associations and underlying disease processes, not solely focusing on intraocular pressure.
  • Clinicians must be familiar with the spectrum of genetic conditions linked to pediatric glaucoma for optimal patient care.