Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.9K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

2.8K
2.8K
Genetic Lingo01:11

Genetic Lingo

116.8K
Overview
116.8K
Glaucoma: Overview01:25

Glaucoma: Overview

1.6K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-Dose Intravitreal Topotecan for Retinoblastoma With Subretinal Seeds: A Well-Tolerated and Efficacious Approach.

Journal of pediatric hematology/oncology·2026
Same author

Retinopathy of Prematurity (ROP): Are We There Yet?

Medicina (Kaunas, Lithuania)·2026
Same author

Anesthesia exposure in unilateral retinoblastoma-comparison of enucleation and intraarterial chemotherapy.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus·2026
Same author

Radiomics to predict high risk features in intraocular retinoblastoma.

Eye (London, England)·2025
Same author

Drug Delivery in Retinoblastoma.

International ophthalmology clinics·2025
Same author

Cavitary retinoblastoma with MYCN amplification.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus·2025

Related Experiment Video

Updated: Mar 15, 2026

Grossing of Non-neoplastic Globes, Including Fetal Eyes
05:15

Grossing of Non-neoplastic Globes, Including Fetal Eyes

Published on: May 30, 2025

665

Pediatric genetic ocular tumors.

Behnaz Rouhani1, Aparna Ramasubramanian2

  • 1Department of Ophthalmology, Drexel University, Philadelphia, PA, USA.

Journal of Pediatric Genetics
|September 15, 2016
PubMed
Summary

Pediatric genetic ocular tumors, including retinoblastoma and phakomatoses, require screening for vision and systemic health. Early detection aids diagnosis and improves outcomes for these childhood eye conditions.

Keywords:
Gardner syndromeGorlin-Gotz syndromeTumorsgeneticneurofibromatosisoptic nerve gliomaretinoblastomatuberous sclerosisvon Hippel-Lindau syndrome

More Related Videos

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

20.3K
Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice
07:55

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

12.2K

Related Experiment Videos

Last Updated: Mar 15, 2026

Grossing of Non-neoplastic Globes, Including Fetal Eyes
05:15

Grossing of Non-neoplastic Globes, Including Fetal Eyes

Published on: May 30, 2025

665
Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

20.3K
Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice
07:55

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

12.2K

Area of Science:

  • Ophthalmology
  • Genetics
  • Pediatrics

Background:

  • Pediatric genetic ocular tumors encompass retinoblastoma and various phakomatoses.
  • These conditions have significant implications for visual prognosis and systemic health.
  • Phakomatoses often present as asymptomatic benign tumors, aiding in syndrome diagnosis.

Purpose of the Study:

  • To review pediatric genetic ocular tumors.
  • To discuss clinical manifestations, diagnosis, and treatment strategies.
  • To highlight the importance of screening for early detection and management.

Main Methods:

  • This is a review article.
  • It synthesizes information on various pediatric genetic ocular tumors.
  • The review covers clinical presentation, diagnostic approaches, and therapeutic options.

Main Results:

  • Retinoblastoma is the most common pediatric malignant intraocular tumor with >95% survival.
  • Germline retinoblastoma is autosomal dominant, necessitating lifelong screening for offspring.
  • Phakomatoses, though often benign, are crucial diagnostic markers for underlying syndromes.

Conclusions:

  • Screening for pediatric genetic ocular tumors is vital for both ocular and systemic health.
  • Timely diagnosis and treatment improve visual outcomes and patient survival.
  • Genetic counseling and surveillance are essential for hereditary conditions like retinoblastoma.