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Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus
Quanyin Hu1,2, Chenggen Qian1,2,3, Wujin Sun1,2
1Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA.
Abstract:
A platelet-membrane-coated biomimetic nanocarrier, which can sequentially target the bone microenvironment and myeloma cells to enhance the drug availability at the myeloma site and decrease off-target effects, is developed for inhibiting multiple myeloma growth and simultaneously eradicating thrombus complication.
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