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Asymmetric Hydrogenation of β-Aryloxy/Alkoxy Cinnamic Nitriles and Esters
Duanyang Kong1, Meina Li1, Rui Wang1
1College of Chemistry, Beijing Normal University , Beijing 100875, China.
Abstract:
A highly efficient and enantioselective hydrogenation of β-aryloxy/alkoxy cinnamic nitriles and esters under mild conditions has been realized by using a rhodium catalyst with a chiral f-spiroPhos ligand. The method provides efficient access to the asymmetric synthesis of a variety of chiral β-oxy-functionalized nitriles and esters with excellent enantioselectivities (up to 99.9% ee) and high turnover numbers (TON of up to 50000). This methodology has also been successfully applied to the concise and practical synthesis of the chiral pharmaceutical nisoxetine.
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