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Updated: Mar 15, 2026
In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
Published on: January 21, 2018
Fluorocoxib A enables targeted detection of cyclooxygenase-2 in laser-induced choroidal neovascularization
Md Jashim Uddin1, Chauca E Moore2, Brenda C Crews1
1Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Institute of Chemical Biology, Department of Biochemistry, Chemistry and Pharmacology, A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Nashville, Tennessee 37232-0146, United States.
Abstract:
Ocular angiogenesis is a blinding complication of age-related macular degeneration and other retinal vascular diseases. Clinical imaging approaches to detect inflammation prior to the onset of neovascularization in these diseases may enable early detection and timely therapeutic intervention. We demonstrate the feasibility of a previously developed cyclooxygenase-2 (COX-2) targeted molecular imaging probe, fluorocoxib A, for imaging retinal inflammation in a mouse model of laser-induced choroidal neovascularization. This imaging probe exhibited focal accumulation within laser-induced neovascular lesions, with minimal detection in proximal healthy tissue. The selectivity of the probe for COX-2 was validated
