Related Experiment Video

Updated: Mar 15, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.6K

[Type 2 diabetes mellitus and heart failure]

Aleš Linhart, Jan Bělohlávek

    Vnitrni Lekarstvi
    |September 15, 2016
    PubMed

    Insights

    Type 2 diabetes mellitus significantly increases heart failure risk. Some diabetes drugs raise this risk, but empagliflozin showed a considerable reduction in a recent trial.

    Area of Science:

    • Cardiology
    • Endocrinology
    • Pharmacology

    Background:

    • Type 2 diabetes mellitus (T2DM) is linked to increased heart failure risk.
    • Mechanisms include coronary heart disease, hypertension, aortic stiffness, arrhythmias, renal failure, and diabetic cardiomyopathy.
    • Certain diabetes medications may also induce heart failure.

    Purpose of the Study:

    • To review evidence on the benefits and harms of diabetes treatments concerning heart failure.
    • To analyze recent randomized trial results.

    Main Methods:

    • Review of current evidence on diabetes treatments and heart failure.
    • Analysis of data from recent randomized controlled trials.

    Main Results:

    • Sulfonylureas, glizatones, and some DPP-4 inhibitors are associated with increased heart failure risk.
    • Empagliflozin demonstrated a significant reduction in heart failure risk in the EMPA-REG OUTCOME trial.

    Conclusions:

    • Diabetes treatment strategies must consider heart failure risks and benefits.
    • Empagliflozin shows promise in mitigating heart failure risk in T2DM patients.
    Abstract

    More Related Videos

    Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model05:58

    Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

    Published on: April 18, 2025

    715
    A Zebrafish Model of Diabetes Mellitus and Metabolic Memory10:03

    A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

    Published on: February 28, 2013

    26.7K

    Related Concept Videos

    Diabetes Mellitus: Type 2 and Gestational01:22

    Diabetes Mellitus: Type 2 and Gestational

    Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
    5.3K
    Carbohydrate Metabolism01:36

    Carbohydrate Metabolism

    Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
    Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
    14.8K
    Heart Failure I: Introduction01:27

    Heart Failure I: Introduction

    Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
    1.1K
    Heart Failure II: Pathophysiology01:29

    Heart Failure II: Pathophysiology

    Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
    1.2K
    Diabetes Mellitus: Overview and Type I Subtype01:22

    Diabetes Mellitus: Overview and Type I Subtype

    Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
    Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
    5.8K
    Heart Failure IV: Classification and Diagnostic Evaluation01:30

    Heart Failure IV: Classification and Diagnostic Evaluation

    Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
    520